| Autor: | Manuel Vásquez, Tomás Adzet, Àgatha Cabrero, Rosa Ma Sánchez, Cristina Rodríguez, Juan C. Laguna, Marta Alegret, Núria Roglans |
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| Rok vydání: | 2001 |
| Předmět: |
PRDM16
chemistry.chemical_classification medicine.medical_specialty Bezafibrate Adipose tissue macrophages Clinical Biochemistry Adipose tissue Fatty acid Cell Biology General Medicine White adipose tissue Biology medicine.anatomical_structure Endocrinology chemistry Biochemistry Internal medicine Brown adipose tissue medicine Molecular Biology Thermogenesis medicine.drug |
| Zdroj: | Molecular and Cellular Biochemistry. 216:71-78 |
| ISSN: | 0300-8177 |
| DOI: | 10.1023/a:1011060615234 |
| Popis: | Rats treated with bezafibrate, a PPAR activator, gain less body weight and increase daily food intake. Previously, we have related these changes to a shift of thermogenesis from brown adipose tissue to white adipose tissue attributable to bezafibrate, which induces uncoupling proteins (UCP), UCP-1 and UCP-3, in rat white adipocytes. Nevertheless, UCP induction was weak, implying additional mechanisms in the change of energy homeostasis produced by bezafibrate. Here we show that bezafibrate, in addition to inducing UCPs, modifies energy homeostasis by directly inducing aco gene expression and peroxisomal fatty acid β-oxidation in white adipose tissue. Further, bezafibrate significantly reduced plasma triglyceride and leptin concentrations, without modifying the levels of PPARγ or ob gene in white adipose tissue. These results indicate that bezafibrate reduces the amount of fatty acids available for triglyceride synthesis in white adipose tissue. |
| Databáze: | OpenAIRE |
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