Treatment of Strontium-89- Induced Hypoplastic Anemia in Mice by Intraperitoneal Implants of Spleen Slices
| Autor: | Gurney Cw, Gaston Eo, J. W. Lyon, B. A. Malcolm, Simmons El |
|---|---|
| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
Hypoplastic anemia business.industry Anemia medicine.medical_treatment Splenectomy Spleen Hypoxia (medical) medicine.disease Pancytopenia Haematopoiesis Endocrinology medicine.anatomical_structure hemic and lymphatic diseases Internal medicine Immunology Medicine Bone marrow medicine.symptom business |
| Zdroj: | Experimental Hematology Today 1979 ISBN: 9781461261810 |
| DOI: | 10.1007/978-1-4612-6179-7_15 |
| Popis: | Strontium-89 (89Sr), a bone-seeking, beta-emitting isotope, causes marrow damage in proportion to the dose administered. With progressively severe marrow aplasia as the 89Sr dose is increased, extramedullar hemopoiesis in the spleen is increased, and essentially normal erythrocyte and thrombocyte levels are maintained (4). Following splenectomy in such animals, however, hypoplastic anemia (pancytopenia) ensues, and if the 89Sr dosage exceeds 2.5 µCi/g, death from hemopoietic failure is common. The mild anemia produced by a small dose of 89Sr and splenectomy can be corrected by weekly injections of testosterone enanthate (3). The hematocrits will also rise if such animals are placed in a hypoxia chamber (3), but the anemia cannot be reversed by injections of syngeneic bone marrow. Marrow cells injected into mice may initially fail to reverse the anemia because colonizing cells that lodge in the femur are killed, or their growth is suppressed by the radiation emitted by the 89Sr absorbed in the bone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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