Inhibition of 5-HETE, LTB4, and LTC4 Formation by Azelastine in Rat Mixed Peritoneal Cells

Autor:	N. Chand, J. Pillar, Duane Sofia, Kevin Nolan, William Diamantis
Rok vydání:	1990
Předmět:	Leukotriene C4 Leukotriene B4 Immunology Ionophore chemistry.chemical_element Radioimmunoassay General Medicine Calcium Azelastine chemistry.chemical_compound medicine.anatomical_structure chemistry Mechanism of action Peritoneum medicine Immunology and Allergy medicine.symptom medicine.drug
Zdroj:	International Archives of Allergy and Immunology. 92:143-147
ISSN:	1423-0097 1018-2438
DOI:	10.1159/000235205
Popis:	Azelastine produced a concentration-dependent inhibition of calcium ionophore A23187 (0.2 μM) stimulated generation of 5-HETE, leukotriene B4, and leukotriene C4 in rat mixed peritoneal cells, yielding IC50 values of 35.5,47.4, and 31.7 μM, respectively. Nordihydroguaiaretic acid (a potent 5-lipoxygenase inhibitor) also exerted a strong and concentration-dependent inhibition of 5-HETE and leukotriene B4 and C4 formation with IC50 values of 0.15, 0.09, and 0.1 μM, respectively. The inhibition of the formation of the products of the lipoxygenase pathway of arachidonic acid metabolism by azelastine may contribute to its overall antiallergic, antiasthmatic, and pulmonary anti-inflammatory activities.
Databáze:	OpenAIRE
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