Synthesis, biological screening and molecular docking studies of novel 4,6-pyrimidine derivatives as EGFR-TK inhibitors
| Autor: | Sharmila Nurbhasha, J.N. Kolla, Hari Babu Bollikolla, Venkatesan Jayaprakash, Lourdu Rani Bhavanam, Siva Nagi Reddy Mule, Surender Singh Jadav |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology Pyrimidine 010405 organic chemistry Chemistry Organic Chemistry Brine shrimp biology.organism_classification 01 natural sciences In vitro 0104 chemical sciences 03 medical and health sciences chemistry.chemical_compound 030104 developmental biology DU145 Biochemistry Bioassay General Pharmacology Toxicology and Pharmaceutics Artemia salina Mode of action Cytotoxicity |
| Zdroj: | Medicinal Chemistry Research. 25:2534-2546 |
| ISSN: | 1554-8120 1054-2523 |
| DOI: | 10.1007/s00044-016-1668-x |
| Popis: | Novel 4, 6-disubstituted pyrimidine derivatives (5–16) were synthesized in four steps starting from 2,4-dichloropyrimidine and screened for their cytotoxicity using brine shrimp (Artemia Salina) lethality bioassay. The compounds such as 6, 11, 14 and 15 were found to be more toxic. The compounds were also studied for in vitro anticancer properties using six different cancer cell lines viz SIHA, PANC-1, MDA-MB-231, IMR-32, DU145 and A549. The compound 14 was effective inhibitor of SIHA and DU145, whereas compound 16 in Panc 1 and A549, compound 7 in MDA-MB-231 and compound 6 in IMR 32 respectively. Molecular docking studies were carried out using an X-ray crystallographic structure of epidermal growth factor receptor tyrosine kinase to explore the possible mode of action of compounds as epidermal growth factor receptor tyrosine kinase inhibitors. |
| Databáze: | OpenAIRE |
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