Cardiovascular Responses During Transition from Fetal to Neonatal Life in Intact and Vagotomized Lambs † 1664

Autor:	Shabih U. Hasan, Ather Bano, Anita Rigaux
Rok vydání:	1998
Předmět:	Fetus Mean blood pressure Respiratory rate business.industry Anesthesia Pediatrics Perinatology and Child Health Heart rate Breathing Medicine Diaphragmatic breathing Left pulmonary artery Blood flow business
Zdroj:	Pediatric Research. 43:284-284
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-199804001-01686
Popis:	Evidence suggests that pulmonary vagal innervation contributes more significantly to the alveolar ventilation in newborns than in older animals. To investigate whether vagal efferents play a role in the control of pulmonary blood flow during transition from fetal to neonatal life, we studied 12 unanesthetized, spontaneously breathing, chronically instrumented newborn lambs at 143-147 d gestation (Term=147±2d) after unassisted vaginal delivery. Surgery was performed between 130-134 d gestation to implant jugular venous and carotid arterial catheters, diaphragmatic electrode and left pulmonary artery blood flow probe (Transonic Inc). Six of 12 fetuses underwent intrathoracic vagotomy (VAG), whereas the remainder six were sham-operated(SHAM). Breathing frequency (breaths per minute) remained higher in the SHAM animals as compared with the VAG group, during the entire postnatal period(92-104 vrs 30-40, respectively; p=0.001). Inspiratory and expiratory times were significantly longer in the VAG group; p
Databáze:	OpenAIRE
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