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Colorectal cancer (CRC) is a global health problem with limited therapeutic opportunities. It is the most common cancer death in the world, mainly due to its higher incidence and metastatic actions. The molecules expressed by the cancer tissues help to develop several novel approaches in cancer treatment. Nowadys, nanotechnology offers an advanced method for the identification and colon cancer therapy which are capable of overcoming biophysical and biochemical barriers in the body. The studies reveal a hope among the scientific community for developing innovative nanoparticles that possess high adaptability for both diagnosis and therapy. It is a most promising area in therapeutics with different design and formulations for the initiation of controlled drug release and uptake into colon cancer tissue. Different nanoparticles like liposomes, carbon nanotubes, nanoshells, polymeric nanoparticles, and dendrimers have been developed to transport a variety of antitumor agents including siRNA, chemo-modulators, and antiangiogenic mediators. Nanotechnology can significantly expand the precision of targeted drug delivery and helps to reduce the toxic side effects. It can also manipulate the interactions in the gut microbiome and the tumor environment which provide an innovative strategy for cancer treatment. This chapter focuses on the different roles of these nanoparticulate technologies and the potential use of nanoparticle formulations in colon cancer therapeutics. Even though several limitations are hindering in the development of nanotechnologies to function as nanotheranostic mediators, which is expected to pave the way for the fight against colon cancer malignancy. |
