Leptin as a Neuroprotector and a Central Nervous System Functional Stability Factor

Autor: N. B. Teryaeva
Rok vydání: 2015
Předmět:
Zdroj: Neuroscience and Behavioral Physiology. 45:612-618
ISSN: 1573-899X
0097-0549
DOI: 10.1007/s11055-015-0120-x
Popis: Adipokines are fatty tissue hormones, a relatively recently discovered class of compounds regulating energy metabolism in virtually all organs and tissues. They include leptin, discovered before and studied better than other adipokines, and evidently associated with the development of a whole series of diseases and pathological states: insulin resistance and diabetes mellitus, cardiovascular system pathology, and oncological and chronic inflammatory diseases. All these states are in one way or another mediated by the influences of leptin on the metabolism of energy substrates and the formation of a proinflammatory state. However, recent years have seen the appearance in the literature of intriguing data on fundamentally different, neurotropic, effects of leptin, suggesting that it has a direct influence on the preservation of neural structures, as well as synapse functioning and transmitter processes. These data allow leptin to be regarded as a neuroprotector, i.e., a neuroplastic factor, and possibly a significant element in realizing specific brain functions. The role of leptin deficiency in lesions to nervous structures and the establishment of the symptoms of central nervous system diseases can also be assessed from this point of view.
Databáze: OpenAIRE
Externí odkaz: