Transcatheter Aortic Valve Replacement With the LOTUS Edge System
| Autor: | Thomas Pilgrim, Fiachra McHugh, Liesbeth Rosseel, Nicole Gilgen, Lars Søndergaard, Mark S. Spence, James Cockburn, Jubin Joseph, Jan Malte Sinning, Georg Nickenig, Marco Angelillis, Brian McGrath, Marek Grygier, Anna Sonia Petronio, Thijmen Hokken, Noman Ali, Daniel J. Blackman, Xavier Armario, Christian Frerker, Nicolas M. Van Mieghem, Nicolas Dumonteil, Darren Mylotte, Saib Khogali, Taishi Okuno, Serdar Farhan, Deepu Balakrishnan, Mohamed Abdel-Wahab, Gaetan Charbonnier, David Hildick-Smith, Rajesh K. Kharbanda, Didier Tchetche, Raban Jeger, Henrik Bjursten, James Cotton, Rui Campante Teles, Ole De Backer |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Transcatheter aortic business.industry Incidence (epidemiology) medicine.medical_treatment Hemodynamics 030204 cardiovascular system & hematology medicine.disease Surgery 03 medical and health sciences 0302 clinical medicine Valve replacement Aortic valve stenosis Cohort Medicine 030212 general & internal medicine Cardiology and Cardiovascular Medicine Adverse effect business Stroke |
| Zdroj: | JACC: Cardiovascular Interventions. 14:172-181 |
| ISSN: | 1936-8798 |
| Popis: | Objectives The aim of this study was to evaluate the short-term safety and efficacy of transcatheter aortic valve replacement (TAVR) with the LOTUS Edge system. Background The LOTUS Edge system was commercially re-released in April 2019. The authors report the first European experience with this device. Methods A multicenter, single-arm, retrospective registry was initiated to evaluate short-term clinical outcomes. Included cases are the first experience with this device and new implantation technique in Europe. Clinical, echocardiographic, and computed tomographic data were analyzed. Endpoints were defined according to Valve Academic Research Consortium-2 and were site reported. Results Between April and November 2019, 286 consecutive patients undergoing TAVR with the LOTUS Edge system at 18 European centers were included. The mean age and Society of Thoracic Surgeons score were 81.2 ± 6.9 years and 5.2 ± 5.4%, respectively. Nearly one-half of all patients (47.9%) were considered to have complex anatomy. Thirty-day major adverse events included death (2.4% [n = 7]) and stroke (3.5% [n = 10]). After TAVR, the mean aortic valve area was 1.9 ± 0.9 cm2, and the mean transvalvular gradient was 11.9 ± 5.7 mm Hg. None or trace paravalvular leak (PVL) occurred in 84.4% and moderate PVL in 2.0%. There were no cases of severe PVL. New permanent pacemaker (PPM) implantation was required in 25.9% among all patients and 30.8% among PPM-naive patients. Conclusions Early experience with the LOTUS Edge system demonstrated satisfactory short-term safety and efficacy, favorable hemodynamic data, and very low rates of PVL in an anatomically complex cohort. New PPM implantation remained high. Further study will evaluate if increasing operator experience with the device and new implantation technique can reduce the incidence of PPM implantation. |
| Databáze: | OpenAIRE |
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