The Role of Leptin in Cancer Pathogenesis
| Autor: | I. Tourkantonis, Maria Kiagia, S. Tsagouli, Konstantinos N. Syrigos, Evangelia Peponi |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Leptin receptor business.industry Leptin digestive oral and skin physiology Adipokine Adipose tissue Systemic inflammation Endocrinology Internal medicine Orexigenic medicine medicine.symptom business Receptor hormones hormone substitutes and hormone antagonists Hormone medicine.drug |
| Zdroj: | Journal of Cancer Therapy. :640-650 |
| ISSN: | 2151-1942 2151-1934 |
| DOI: | 10.4236/jct.2013.42080 |
| Popis: | Leptin is a hormone produced and secreted by adipose tissue. It is a member of adipokine family with a principal role in body weight regulation. It is reported that low brain leptin levels enhance the activity of hypothalamic orexigenic signals promoting feeding and suppressing energy expenditure and vice versa. Moreover, leptin via its three receptors participates in multiple neuroendocrine loops regulation. Serum leptin levels are positively associated with BMI (Body Mass Index) and whilst interact not only with other cytokines but also with serum insulin and cortisol levels. The aim of the present review is to study the role of leptin in carcinogenesis and its implications in cancer-related systemic inflammation. |
| Databáze: | OpenAIRE |
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