Cardiovascular outcomes among sildenafil users: results of the International Men’s Health Study
| Autor: | H. Hedelin, Gillian C. Hall, Dale B. Glasser, Rachel E. Sobel, Murray A. Mittleman, Robert F. Reynolds, Hartmut Porst, Antonio Martin-Morales, M. A. Lewis, Nicholas Moore, François Giuliano, Malcolm Maclure |
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| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
medicine.drug_mechanism_of_action business.industry Sildenafil Incidence (epidemiology) General Medicine medicine.disease Surgery chemistry.chemical_compound Erectile dysfunction chemistry Emergency medicine medicine cardiovascular diseases Myocardial infarction Medical prescription business Phosphodiesterase 5 inhibitor Stroke Cohort study |
| Zdroj: | International Journal of Clinical Practice. 62:367-373 |
| ISSN: | 1368-5031 |
| DOI: | 10.1111/j.1742-1241.2007.01679.x |
| Popis: | Summary Aim: To assess the incidence of serious cardiovascular disease (CVD) events [i.e. myocardial infarction (MI) and stroke] and all-cause mortality in men with erectile dysfunction (ED) who received prescriptions for sildenafil. Methods: The International Men’s Health Study (IMHS) was a prospective, observational cohort study of patients with ED and a new or existing prescription for sildenafil. Baseline and follow-up questionnaires provided information on demographics, CVD risk factors and ED. Postevent questionnaires were mailed to patients following possible nonfatal CVD events to collect information related to exposure to sildenafil/ED treatments before the event. Results: Thirty-five CVD events were reported in 30 patients in the analysis set (n = 3813). The incidence of all-cause mortality, MI and stroke was 0.4, 0.6 and 0.1 per 100 patient-years of observation respectively. Among the six men who reported using sildenafil in the month before a nonfatal CVD event, two reported use in the 24 h before the event. Conclusion: The results of the IMHS support previous reports that ED and CVD are often comorbid and share risk factors. |
| Databáze: | OpenAIRE |
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