Quality of pathologic response and surgery correlate with survival for patients with completely resected bladder cancer after neoadjuvant chemotherapy

Autor:	Ronald B. Natale, Bryan Goldman, H. Barton Grossman, David P. Wood, Guru Sonpavde, Seth P. Lerner, Donald L. Trump, E. David Crawford, V. O. Speights, Nicholas J. Vogelzang
Rok vydání:	2009
Předmět:	Cancer Research Chemotherapy medicine.medical_specialty Bladder cancer business.industry Carcinoma in situ medicine.medical_treatment Cancer medicine.disease Vinblastine Surgery Cystectomy Oncology Medicine business Survival analysis Neoadjuvant therapy medicine.drug
Zdroj:	Cancer. 115:4104-4109
ISSN:	1097-0142 0008-543X
DOI:	10.1002/cncr.24466
Popis:	BACKGROUND: In a retrospective study of Southwestern Oncology Group (SWOG)-S8710/INT-0080 (radical cystectomy [RC] alone vs 3 cycles of neoadjuvant chemotherapy [NC] with methotrexate, vinblastine, doxorubicin, and cisplatin before RC for bladder cancer), factors found to be associated with improved overall survival (OS) included pathologic complete response, defined as P0; treatment with NC; completion of RC with negative surgical margins; and � 10 pelvic lymph nodes (LNs) removed. METHODS: The authors used stratified Cox regression to retrospectively study the association of quality of pathologic response after RC with OS in the subset of S8710 patients who received NC and RC with negative surgical margins. RESULTS: Of 154 patients who received NC, 68 (44.2%) were
Databáze:	OpenAIRE
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