| Autor: |
D.B. Clayson, J.J. Childs |
| Rok vydání: |
1966 |
| Předmět: |
|
| Zdroj: |
Biochemical Pharmacology. 15:1247-1258 |
| ISSN: |
0006-2952 |
| DOI: |
10.1016/0006-2952(66)90034-7 |
| Popis: |
The seven known monohydroxy-derivatives of 1-phenylazo-2-naphthol may be separated by thin film chromatography on silica plates by the use of two solvent systems. The metabolites of 1-phenylazo-2-naphthol in the bile and urine of the rabbit have been examined and the following compounds identified using a combination of enzymatic, chromatographic and spectroscopic techniques: glucuronides of 4′,6-dihydroxy-1-phenylazo-2-naphthol and 4′- and 6-hydroxy-1-phenylazo-2-naphthol were present in both bile and urine; the N-glucuronides of 1-phenylhydrazo-2-naphthol and 4′-hydroxy-1-phenylhydrazo-2-naphthol and also 1-amino-2-naphthyl hydrogen sulphate and 1-amino-2-naphthyl glucuronide were present in the urine. Less precise information has been obtained on the identity of certain other metabolites. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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