Detection of Lewisite-2 in the Presence of Alcohols and/or Thiodiglycol in Aqueous Matrices

Autor:	Mieczysław S. Sokołowski, Zlatko Fröbe, Leszek Konopski
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Aqueous solution Lewisite Chemistry Organic Chemistry Sulfur mustard Thiodiglycol Biochemistry Inorganic Chemistry chemistry.chemical_compound Organic chemistry Derivatization Derivative (chemistry) Alkyl Dichloromethane
Zdroj:	Phosphorus, Sulfur, and Silicon and the Related Elements. 183:1630-1640
ISSN:	1563-5325 1042-6507
DOI:	10.1080/10426500701708137
Popis:	Bis(2-chlorovinyl)chloroarsine (Lewisite-2) was detected in water in the presence of selected alcohols, thiols, hydroxy thiols and diols. The expected alkyl bis(2-chlorovinyl)arsinites or corresponding arsinodithiolites were obtained with alcohols and thiols, whereas reactions with bifunctional hydroxythiols and diols afforded S-thio monoesters or diesters, respectively. This reaction was found useful to smoothly transform at 40°C bis(2-hydroxyethyl) sulfide (thiodiglycol, a sulfur mustard decomposition product), into a stable diarsinite derivative, thiodiglycol bis[bis(2-chlorovinyl)]arsinite. After extraction with dichloromethane, the derivative may be detected easily and selectively using GS/MS, eliminating time-consuming evaporation and derivatization. The method may be applied to analyze Chemical Weapons Convention related environmental water samples.
Databáze:	OpenAIRE
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