The effect of aqueous extract of zest of citrus sinensis (AEZCs) on cadmium chloride induced liver toxicity in wistar rats
| Autor: | Ikwuka David, Eze Wenceslaus, Nworgu Choice, Augustine Ndubuisi, Anyaeji Pamela, N Daniel, Agu Francis Uchenna, Ugwuishi Emeka, Ude Victor Chibueze, Ani Celestine, Ugwudike Patrick |
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| Rok vydání: | 2020 |
| Předmět: |
Aqueous extract
Cadmium chemistry.chemical_element Pharmacology Cadmium chloride medicine.disease_cause Malondialdehyde 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine chemistry 030220 oncology & carcinogenesis medicine Potency 030211 gastroenterology & hepatology Pharmacology (medical) Dismutase Oxidative stress Citrus × sinensis |
| Zdroj: | African Journal of Biochemistry Research. 14:5-17 |
| ISSN: | 1996-0778 |
| Popis: | The potency of the peels of Citrus sinensis against cadmium induced liver damage has not been explored in our environment. 48 wistar rats were used for this study. The animals were randomly divided into eight (8) groups of five (5) rats each. Group A was the positive control and received 5 mg/kg body weight (bw) of cadmium chloride (CdCl2) intraperitoneally as a single dose. Groups B and C received the aqueous extract of zest of citrus sinensis (AEZCS) at a low doses of 10 and 40 mg/kg bw respectively. Groups D and E received cadmium chloride, followed by low and high doses of AEZCS respectively. Groups F and G received low and high doses of AEZCS followed by CdCl2 while group H served as the normal control. Liver enzymes (AST, ALT and ALP) and serum total proteins were analyzed. The results showed significant (P |
| Databáze: | OpenAIRE |
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