| Autor: |
Oliver D. Howes, Lula Rosso, P J Cowen, Paul Faulkner, Elias Mouchlianitis, Federico Turkheimer, J. P. Roiser, Sudhakar Selvaraj |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
European Psychiatry. 27:1 |
| ISSN: |
0924-9338 |
| Popis: |
Background Serotonin (5-HT) is thought to be critical for affect regulation in the brain and many antidepressants are thought to primarily work by altering 5-HT levels. However there has not been a validated means of directly imaging of endogenous 5-HT levels in humans. The main aims of this project are to image the effect of Citalopram on brain endogenous 5-HT levels and to determine the relationship between brain 5-HT and affect regulation. Methods Thirteen healthy volunteers (mean age 50.9yrs, range 35–63) underwent two Positron Emission Tomography (PET) scans with [ 11 C]-CUMI, a highly selective 5-HT 1A agonist radioligand. Subjects received either a slow intravenous infusion of citalopram 10mg or saline starting 45 minutes before each PET scan in a randomized design. All subjects had a functional MRI emotion processing task (block design) known to activate the amygdala on a separate day. Results The citalopram infusion induced 6–11% increases in [ 11 C]-CUMI binding potential in anterior cingulate, insula and cortical brain regions (p BOLD response to fearful vs neutral faces in the left amygdala inversely correlated with baseline dorsal raphe BP (Pearson r 2 =−0.90, p 2 =0.51, p = 0.07). Conclusion The increase in [ 11 C]CUMI-101 availability would be consistent with a decrease in endogenous 5-HT availability in certain terminal regions. The relationship between brain emotion processing and [ 11 C]-CUMI binding in the raphe indicates the 5-HT levels at presynaptic receptors regulate emotional processing and suggests presynaptic 5-HT as a treatment target for affective disorders. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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