| Autor: |
Dustin Möbius, Moritz Gerling, Alexandra Ron, Inga Kniep, Jan-Peter Sperhake, Markus Glatzel, Larissa Lohner, Hanna Goebels, Antonia Zapf, Anna Lina Gerberding, Daniela Fröb, Carla Falck, Philine Lange, Carolin Edler, Benjamin Ondruschka, Antonia Fitzek, Kira Meißner, Marc Lütgehetmann, Christoph Torns, Jakob Matschke, Stefan Steurer, Felicitas Langenwalder, Fabian Heinrich, Ann Sophie Schröder, Sven Anders, E. Dietz, Sandra Wilmes, Julia Schädler, Martin Aepfelbacher, Axel Heinemann, Klaus Püschel, Herbert Mushumba, Anna Lena Kammal, Anke Klein |
| Rok vydání: |
2021 |
| Předmět: |
|
| DOI: |
10.21203/rs.3.rs-670066/v1 |
| Popis: |
BackgroundCoronavirus disease 19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic with significant mortality. Accurate information on the specific circumstances of death and whether patients died from or with SARS-CoV-2 is scarce.MethodsTo distinguish COVID-19 from non-COVID-19 deaths, we performed a systematic review of 735 SARS-CoV-2-associated deaths in Hamburg, Germany, from March to December 2020, using conventional autopsy, ultrasound-guided minimally invasive autopsy, postmortem computed tomography and medical records. Statistical analyses including multiple logistic regression were used to compare both cohorts.Findings84.1% (n=618) were classified as COVID-19 deaths, 6.4% (n=47) as non-COVID-19 deaths, 9.5% (n=70) remained unclear. Median age of COVID-19 deaths was 83.0 years, 54.4% were male. In the autopsy group (n=283), the majority died of pneumonia and/or diffuse alveolar damage (73.6%; n=187). Thromboses were found in 39.2% (n=62/158 cases), pulmonary embolism in 22.1% (n=56/253 cases). In 2020, annual mortality in Hamburg was about 5.5% higher than in the previous 20 years, of which 3.4% (n=618) represented COVID-19 deaths.InterpretationOur study highlights the need for mortality surveillance and postmortem examinations. The vast majority of individuals who died directly from SARS-CoV-2 infection were of advanced age and had multiple comorbidities. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
