ChemInform Abstract: High 1,6-Diastereoselectivity in the Hydride Reduction of an Acyclic Ketone Substrate via Bicyclic Chelation Control

Autor:	Bruce D. Harris, Bruce E. Maryanoff, Cynthia A. Maryanoff, Han-Cheng Zhang
Rok vydání:	2010
Předmět:	chemistry.chemical_classification Ketone Bicyclic molecule Hydride Diastereomer General Medicine Chloride Medicinal chemistry chemistry.chemical_compound chemistry medicine Stereoselectivity Chelation Methylene medicine.drug
Zdroj:	ChemInform. 28
ISSN:	0931-7597
Popis:	Reduction of acyclic e-hydroxy ketone 3 with R-Alpine-Hydride® in methylene chloride provided a strong preponderance of the anti diastereomer of 4 (anti:syn = 12:1). This impressive 1,6 stereoselectivity is attributed to bicyclic chelation control of hydride addition.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1f8b8361f49219540a69a109b397e46a https://doi.org/10.1002/chin.199706058 Zobrazit plný text záznamu Plný text