Antibacterial Activity of Short Peptides Based on Pleurocidin and Their Interaction with Phospholipid Membranes

Autor:	Nobuaki Tsuda, Setsuko Ando, Haruhiko Aoyagi, Yoshiki Uchida, Tomomitsu Hatakeyama, Yukari Koba, Mitsuno Shindo
Rok vydání:	2008
Předmět:	chemistry.chemical_compound medicine.anatomical_structure Membrane chemistry Biochemistry Cell medicine Phospholipid Pleurocidin General Chemistry Amino acid residue Antibacterial activity Combinatorial chemistry
Zdroj:	Bulletin of the Chemical Society of Japan. 81:1299-1303
ISSN:	1348-0634 0009-2673
DOI:	10.1246/bcsj.81.1299
Popis:	We have studied antibacterial activities of model peptides based on Pleurocidin (Ple). In this study, to investigate the effect of the C-terminal portion of these model peptides on antibacterial activity, we synthesized several short peptides which are devoid of the C-terminal four and more amino acid residues from the corresponding model peptides and examined their biological activities and behaviors against lipid and cell membranes. Removal of the C-terminal four residues resulted in maintained antibacterial activity and reduction of hemolytic activity.
Databáze:	OpenAIRE
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