Paracoccidioidomycosis due to Paracoccidioides brasiliensis S1 associated with acquired immunodeficiency syndrome: A case report
| Autor: | Anderson Messias Rodrigues, Simone Bravim Maifrede, Carlos Urbano Gonçalves Ferreira Júnior, Tânia Regina Grão-Velloso, Sarah Santos Gonçalves, Claudia Biasutti, Breno Gonçalves Pinheiro, Wdson Luis Lima Kruschewsky, Zoilo Pires de Camargo, Aloísio Falqueto, Paulo Mendes Peçanha, Isabela Cruz Bahiense |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Paracoccidioides brasiliensis
0303 health sciences biology 030306 microbiology business.industry Paracoccidioidomycosis medicine.disease biology.organism_classification Ouchterlony double immunodiffusion Microbiology Paracoccidioides 03 medical and health sciences Infectious Diseases Acquired immunodeficiency syndrome (AIDS) Immunology medicine skin and connective tissue diseases Abscess business Generalized lymphadenopathy Molecular identification |
| Zdroj: | Revista Iberoamericana de Micología. 38:5-8 |
| ISSN: | 1130-1406 |
| DOI: | 10.1016/j.riam.2020.09.003 |
| Popis: | Background Paracoccidioidomycosis (PCM) is an endemic disease in Latin America. In immunocompetent hosts, PCM occurs in two main clinical forms: acute and chronic. However, in HIV-infected patients PCM may show up simultaneous manifestations of acute and chronic forms. Case report We present the case of a patient diagnosed with HIV who had disseminated skin lesions and generalized lymphadenopathy, as well as respiratory and central nervous system involvement. The PCM diagnosis was confirmed by direct KOH examination, double immunodiffusion and the isolation of the fungus in samples of an abscess in the subcostal region. The isolate was identified as Paracoccidioides brasiliensis S1 by species-specific PCR using primers for protein-coding gene GP43 (exon 2) followed by PCR-RFLP of the alpha-tubulin gene. Conclusions There are few data in literature reporting species-specific molecular identification of Paracoccidioides in HIV/PCM patients. Therefore, this case report may contribute to improve the knowledge about this severe disease, its causative cryptic species, and its consequences to patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect