Phosphorylcholine−Carbohydrate− Protein Conjugates Efficiently Induce Hapten-Specific Antibodies Which Recognize BothStreptococcuspneumoniaeandNeisseriameningitidis: A Potential Multitarget Vaccine against Respiratory Infections
| Autor: | Pierre Lafaye, Muhamed-Kheir Taha, Joël Ughetto-Monfrin, Sylvie Bay, René Pires, Valérie Huteau, Maria Leticia Zarantonelli, Patrick England |
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| Rok vydání: | 2004 |
| Předmět: |
genetic structures
CHOP medicine.disease_cause Microbiology 03 medical and health sciences immune system diseases hemic and lymphatic diseases Drug Discovery Streptococcus pneumoniae polycyclic compounds medicine 030304 developmental biology 0303 health sciences biology 030306 microbiology Chemistry Phosphorylcholine Neisseria meningitidis Streptococcaceae biology.organism_classification Virology eye diseases 3. Good health biology.protein Molecular Medicine Neisseriaceae Antibody Hapten |
| Zdroj: | Journal of Medicinal Chemistry. 47:3916-3919 |
| ISSN: | 1520-4804 0022-2623 |
| DOI: | 10.1021/jm040783p |
| Popis: | Phosphorylcholine (ChoP) is commonly expressed at the surface of pathogens of the respiratory tract, including Streptococcus pneumoniae and Neisseria meningitidis. We designed a synthetic hapten comprising ChoP and part of its native carrier structure in S. pneumoniae, i.e. N-acetyl-d-galactosamine (GalNAc). Protein conjugates of this hapten induced GalNAc−ChoP-specific antibodies which recognized ChoP on both S. pneumoniae and N. meningitidis. GalNAc−ChoP could therefore lead to the rational design of a novel multipurpose vaccine against respiratory infections. |
| Databáze: | OpenAIRE |
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