Detection of the t(2;5)-associated NPM/ALK fusion cDNA in peripheral blood cells of healthy individuals

Autor:	Lorenz Trümper, Heiner Daus, F V Bonin, Michael Pfreundschuh
Rok vydání:	1998
Předmět:	Nucleophosmin medicine.medical_specialty integumentary system CD30 Kinase Cytogenetics Chromosome Chromosomal translocation Hematology Biology medicine.disease Molecular biology Lymphoma immune system diseases hemic and lymphatic diseases medicine Anaplastic lymphoma kinase
Zdroj:	British Journal of Haematology. 103:1138-1144
ISSN:	0007-1048
DOI:	10.1046/j.1365-2141.1998.01097.x
Popis:	The translocation t(2;5), which leads to the fusion of the nucleophosmin gene (NPM) on chromosome 5q35 to the receptor kinase ALK on chromosome 2p23, is found in CD30+ anaplastic large cell lymphomas and some cases of B-cell lymphoma. Hodgkin's disease (HD) is a malignant lymphoma characterized by large multinucleated tumour cells, Hodgkin and Reed-Sternberg (HR18) and t(9;22), t(2;5) represents the third example of tumour-associated translocation products in blood cells of apparently healthy donors. The implications of this finding are discussed.
Databáze:	OpenAIRE
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