| Autor: |
Pinto Paula, Margarida Aguiar, Bárbara Cristina, Richard Staats, Bugalho António, João Valença, Dina Fernandes, Rachel Rodrigues, Luis F. Moita, Susana Moreira |
| Rok vydání: |
2016 |
| Předmět: |
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| Zdroj: |
4.2 Sleep and Control of Breathing. |
| DOI: |
10.1183/13993003.congress-2016.pa2069 |
| Popis: |
Introduction: Sleep related breathing disorders (SRBD) influence the human homeostasis by sleep fragmentation, intermittent hypoxia (IH) or a combinations of both. Effected compartments include the immune system and metabolic parameters. We investigated if patients with or without IH demonstrate different patterns. Methods: 87 participants were divided into 4 groups: healthy controls (C: n=24), patients with sleep fragmentation related to increased upper airway resistance but without IH (UAR: n=19), obstructive sleep apnea (OSA) with (oOSA: n=25) or without obesity (noOSA: n=20). Following polysomnographic recording we analyzed perforin and granzyme-B (GrB) positive lymphocyte subpopulations and fasting routine analysis. The Kruskal-Wallis test and related multiple comparisons were used to compare groups. Results: All three SRBD groups revealed a decreased percentage of perforin + CD3 + gd-T cells when compared to controls. However, after adjustment calculation, only oOSA remained statistically significant (p + CD4 + , CD3 + CD8 + , CD3 - CD8 + , CD3 + CD16 + /CD56 + and CD3 - CD16 + /CD56 + lymphocytes. Serum Gamma-Glutamyl transpeptidase was higher in all three SRBD groups, while elevated triglyceride was only detected in both OSA groups. Only oOSA was associated with significantly higher glucose and C-reactive protein values. Conclusion: Compared to controls we found significantly different results in patients with SRBD. A reduced percentage of perforin + CD3 + gd-T cells was encountered in all three SRBD groups, while other results were linked to IH. This study indicates a possible systemic effect of non hypoxic SRBD. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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