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A series of 1,8-naphthyridine derivatives 3(a-g) and 4(a-g) as potential antibacterial agents were designed and efficiently amination of 2-chloro-3-aryl-1,8-naphthyridines 1(a-g) with various anilines substituents in positions two. All synthesized target compounds were characterized by 1H NMR, 13C NMR and MS spectra. All the synthesized compounds were evaluated for their anti-bacterial activity against P. aeruginosa, E.coli (Gram -ve bacteria) and S.aureus, B.subtilis (Gram +ve bacteria) in contrast with the clinical Ciprofloxacin. The molecular docking study was succeeded to understand the likely interactions with the new synthesized compounds 3(a-g) and 4(a-g). Docking investigation demonstrated that active molecule 3b, 3e and 4b, 4e, 4g have better docking score with protein. |
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