Comparison of Effect of Endothelin Antagonism and Angiotensin-Converting Enzyme Inhibition on Blood Pressure and Vascular Structure in Spontaneously Hypertensive Rats Treated With N ω -Nitro- l -Arginine Methyl Ester
| Autor: | Christian F. Deschepper, Kevin L. Grove, Jin S. Li, Li Y. Deng, Ernesto L. Schiffrin |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
medicine.hormone
medicine.medical_specialty Endothelium biology business.industry Angiotensin-converting enzyme Cilazapril Endothelin 1 Bosentan Endothelins medicine.anatomical_structure Endocrinology Internal medicine cardiovascular system Internal Medicine medicine biology.protein Endothelin receptor business Mesenteric arteries medicine.drug |
| Zdroj: | Hypertension. 28:188-195 |
| ISSN: | 1524-4563 0194-911X |
| DOI: | 10.1161/01.hyp.28.2.188 |
| Popis: | Inhibition of nitric oxide synthase by l -arginine analogues such as N ω -nitro- l -arginine methyl ester (L-NAME) in spontaneously hypertensive rats (SHR) is associated with malignant hypertension and enhanced expression of the endothelin-1 gene in some blood vessels. In this study, SHR treated chronically with L-NAME (SHR–L-NAME) were given the angiotensin I–converting enzyme inhibitor cilazapril or the endothelin-A/endothelin-B receptor antagonist bosentan for 3 weeks. Systolic pressure was lowered slightly by cilazapril (213±2 versus 229±2 mm Hg in untreated SHR–L-NAME, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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