Fluoropyridyl Sugars – Masked Imidate Glycosyl Donors that Display Reactivity, Selectivity, and Stability
| Autor: | Kavnen Tseke, Ray Leslie, L. Seetohul, Agneta Vitkute, Sophie L. Benjamin |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
animal structures Glycosylation 010405 organic chemistry Chemistry Stereochemistry Organic Chemistry Chemical glycosylation Glycoside macromolecular substances 010402 general chemistry 01 natural sciences 0104 chemical sciences carbohydrates (lipids) chemistry.chemical_compound lipids (amino acids peptides and proteins) Reactivity (chemistry) Glycosyl Stereoselectivity Glycosyl donor Selectivity |
| Zdroj: | Synlett. 28:2131-2134 |
| ISSN: | 1437-2096 0936-5214 |
| Popis: | Fluoropyridyl glycosides, synthesized from the corresponding glycosyl bromides, are shown to be excellent donors in glycosylation reactions. Both armed and disarmed donors were prepared and reacted smoothly with a series of glycosyl acceptors. Coupling proceeded in high yields, with activation of the donor achieved using a range of promoters, and also displayed unusually high selectivity. In addition these novel systems offer the potential for introducing a series of glycosyl donors with ‘tunable reactivity’. |
| Databáze: | OpenAIRE |
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