Fluoropyridyl Sugars – Masked Imidate Glycosyl Donors that Display Reactivity, Selectivity, and Stability

Autor: Kavnen Tseke, Ray Leslie, L. Seetohul, Agneta Vitkute, Sophie L. Benjamin
Rok vydání: 2017
Předmět:
Zdroj: Synlett. 28:2131-2134
ISSN: 1437-2096
0936-5214
Popis: Fluoropyridyl glycosides, synthesized from the corresponding glycosyl bromides, are shown to be excellent donors in glycosylation reactions. Both armed and disarmed donors were prepared and reacted smoothly with a series of glycosyl acceptors. Coupling proceeded in high yields, with activation of the donor achieved using a range of promoters, and also displayed unusually high selectivity. In addition these novel systems offer the potential for introducing a series of glycosyl donors with ‘tunable reactivity’.
Databáze: OpenAIRE