Sinergia en la analgesia tratada con ibuprofeno y codeína

Autor: J. Frías-Iniesta, J.L. López-Durán
Rok vydání: 2012
Předmět:
Zdroj: SEMERGEN - Medicina de Familia. 38:24-32
ISSN: 1138-3593
DOI: 10.1016/j.semerg.2011.07.012
Popis: One of the principal characteristics of a good pharmacological combination is drug synergism. A new analgesic combination of ibuprofen, a non-steroidal anti-inflammatory drug, used frequently in clinical practice due to good quotient of efficacy and safety, and codeine, a minor opiate used very much as second analgesic step in combination, has recently come on the market. We have conducted a review in MEDLINE of the principal studies published in the medical literature as regards the efficacy and safety of both drugs separately and finally, a review of the clinical experience showed in studies with analgesic combinations in general and on the hypothesis of a possible drug synergism between NSAIDs and Opiates.
Databáze: OpenAIRE