An Efficient Chan-Lam S -Arylation of Arylthioureas with Arylboronic Acids

Autor:	Zhi-Bing Dong, Han-Ying Peng, Shi-Bo Zhang, Yu Cheng, Hui Zhu, Xing Liu
Rok vydání:	2018
Předmět:	Reaction conditions 010405 organic chemistry Ligand Organic Chemistry 010402 general chemistry 01 natural sciences Combinatorial chemistry Coupling reaction 0104 chemical sciences Catalysis chemistry.chemical_compound Bipyridine chemistry Reagent Organic synthesis Physical and Theoretical Chemistry
Zdroj:	European Journal of Organic Chemistry. 2018:4483-4489
ISSN:	1434-193X
DOI:	10.1002/ejoc.201800892
Popis:	A convenient and efficient protocol has been developed for the preparation of aryl-isothioureas based on the Chan-Lam C-S coupling reaction. The desired aryl-isothioureas were synthesized in good yields (up to 95%) in the presence of Cu(OAc)(2)H2O as catalyst and bipyridine as ligand. A variety of functional groups on the aryl-thiourea and arylboronic acid reagents are tolerated. The method features mild reaction conditions and good yields, thereby illustrating its practical synthetic value in organic synthesis.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1f4010fc8019448740fdb9c348e78939 https://doi.org/10.1002/ejoc.201800892 Zobrazit plný text záznamu Plný text ve formátu PDF