Progenitor cell mobilization by granulocyte colony-stimulating factor controlled by loci on chromosomes 2 and 11

Autor:	Donald Metcalf, Tracey M. Baldwin, Simon J. Foote, Masakazu Hasegawa
Rok vydání:	2000
Předmět:	Immunology Cell Biology Hematology Biology Granulocyte Biochemistry Molecular biology Granulocyte colony-stimulating factor Transplantation Haematopoiesis medicine.anatomical_structure medicine Bone marrow Progenitor cell Stem cell Progenitor
Zdroj:	Blood. 95:1872-1874
ISSN:	1528-0020 0006-4971
Popis:	Granulocyte colony-stimulating factor (G-CSF) can effectively mobilize hematopoietic stem and progenitor cells from bone marrow into blood, thereby allowing peripheral blood stem cells (PBSCs) to be used for transplantation. The efficiency of PBSC mobilization response to G-CSF is a multigene trait. DBA/2 (high-responder) and C57BL/6 (low-responder) mice were used for a genetic analysis of G-CSF–induced progenitor release. Significant linkages were found on chromosome 2 by analyzing segregation distortion among the high responders of 500 backcross mice and on chromosome 11 by using the quantitative trait locus analysis of 26 strains of BXD recombinant inbred mice.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1f305644057b56c147aa90609468fd50 https://doi.org/10.1182/blood.v95.5.1872.005k26_1872_1874 Zobrazit plný text záznamu