Drug release from PLA/PEG microparticulates
| Autor: | Tze Wen Chung, Tzeng Wen Tzeng, Yi You Huang |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Coacervate
Chemistry technology industry and agriculture Pharmaceutical Science macromolecular substances respiratory system Biodegradable polymer Dosage form stomatognathic system Chemical engineering PEG ratio Emulsion Polymer chemistry Copolymer lipids (amino acids peptides and proteins) Dissolution testing Drug carrier |
| Zdroj: | International Journal of Pharmaceutics. 156:9-15 |
| ISSN: | 0378-5173 |
| DOI: | 10.1016/s0378-5173(97)00154-3 |
| Popis: | Drug-loaded biodegradable PLA, PLA/PEG microspheres were prepared by the coacervation technique, by solvent evaporation and by the emulsion method. The effects of drug properties, particle size, drug loading and method of microencapsulation on the in vitro drug dissolution were also examined. According to the results, PLA/PEG copolymer was more hydrophilic than PLA homopolymer, and with lower glass transition temperature. PLA/PEG microparticulates were not as smooth as that of PLA. Drug release from microspheres was effected by the properties of PLA/PEG copolymers. The release rate of the hydrophobic drug, lidocaine, encapsulated in the polymer PLA/PEG copolymer, was faster than that in a pure PLA homopolymer. The same results also held for the hydrophilic drug, propranolol hydrochloride. Microspheres obtained by the emulsion method were porous and with adequate drug permeability. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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