Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease
| Autor: | Sarah Marakos, Gary D. Wu, Judith R. Kelsen, Casey E. Hofstaedter, Joseph P. Zackular, Lisa M. Mattei, Michael Moraskie, Huanjia Zhang, Jessi Erlichman, Jessica Breton, Kyle Bittinger, Hongzhe Li, Robert Baldassano, Kevin J. Downes, Frederic D. Bushman, Christopher Petucci, James D. Lewis, Alissa Galgano, Jessica Hart, Minsoo Kim, Arwa Abbas, Kelly Kachelries, Dorothy Kim, Maire A. Conrad, Christopher H Gu, Chunyu Zhao, Yue Ren, Nina Devas |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Taurine
genetic structures Metabolite Inflammation Disease Biology digestive system Microbiology Inflammatory bowel disease 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Virology medicine Metabolome Microbiome 030304 developmental biology 0303 health sciences Omics medicine.disease digestive system diseases chemistry Immunology Parasitology medicine.symptom 030217 neurology & neurosurgery |
| Zdroj: | Cell Host & Microbe. 28:422-433.e7 |
| ISSN: | 1931-3128 |
| Popis: | Summary Children with inflammatory bowel diseases (IBD) are particularly vulnerable to infection with Clostridioides difficile (CDI). IBD and IBD + CDI have overlapping symptoms but respond to distinctive treatments, highlighting the need for diagnostic biomarkers. Here, we studied pediatric patients with IBD and IBD + CDI, comparing longitudinal data on the gut microbiome, metabolome, and other measures. The microbiome is dysbiotic and heterogeneous in both disease states, but the metabolome reveals disease-specific patterns. The IBD group shows increased concentrations of markers of inflammation and tissue damage compared with healthy controls, and metabolic changes associate with susceptibility to CDI. In IBD + CDI, we detect both metabolites associated with inflammation/tissue damage and fermentation products produced by C. difficile. The most discriminating metabolite found is isocaproyltaurine, a covalent conjugate of a distinctive C. difficile fermentation product (isocaproate) and an amino acid associated with tissue damage (taurine), which may be useful as a joint marker of the two disease processes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|