Assessment of a Serum Assay for Quantification of Abdominal Aortic Calcification

Autor:	Rumal Jayalath, Lisa Oliver, Petra Buttner, Jonathan Golledge, Paula Clancy
Rok vydání:	2006
Předmět:	Pathology medicine.medical_specialty biology business.industry Aortic calcification Osteoprotegerin Abdominal aortic calcification Blood assay biology.protein Medicine Osteopontin Risk factor Cardiology and Cardiovascular Medicine business Prospective cohort study Vascular calcification
Zdroj:	Arteriosclerosis, Thrombosis, and Vascular Biology. 26:2574-2576
ISSN:	1524-4636 1079-5642
DOI:	10.1161/01.atv.0000242799.81434.7d
Popis:	Intimal vascular calcification is an important marker of atherosclerosis, and its severity is an independent risk factor for cardiovascular events. Measurement of coronary or aortic calcification requires CT-based imaging and elaborate data analysis to ensure accuracy. A blood assay which could quantify the severity of vascular calcification would be less expensive, avoid exposure to radiation, and be more accessible than present imaging based methods. Osteoprotegerin (OPG) and osteopontin (OPN) are present in human serum and have been implicated in vascular calcification. In this prospective study we assessed the value of a number of serum assays for OPG and OPN in determining abdominal aortic calcification. Firstly, we investigated the assay characteristics and reproducibility of 5 ELISAs using a subset of patients. Based on the findings of these assessments, we selected 3 assays for full evaluation in the entire cohort.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1f291eb266e39f05273301128ad7c7ba https://doi.org/10.1161/01.atv.0000242799.81434.7d Zobrazit plný text záznamu