| Autor: |
April Williams, Damien Mor, Hiep D. Le, Renaud Rovera, Howard M. Cooper, Ouria Dkhissi-Benyahya, Nasser Haddjeri, Sarah Delcourte, Adeline Etievant, Rihab Azmani, Christine Coutanson, Olivier Raineteau, Satchidananda Panda |
| Rok vydání: |
2020 |
| Předmět: |
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| Popis: |
Successful antidepressant (AD) treatments are still difficult to achieve. Recently, bright light stimulation (BLS) was shown effective in non-seasonal depression but its mode of action remains elusive. We demonstrate here, using a new mouse model of depression resistant to ADs including ketamine, that chemogenetic activation of lateral habenula (LHb) astroglia prevented the potentiating effect of BLS on the AD response. Additionally, the beneficial action of BLS was associated with upregulation of a specific part of the prefrontal cortex opioid system. These results show that improved behavioral outcome produced by BLS requires habenular astroglia and endogenous opioids as crucial buffer systems. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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