ChemInform Abstract: AS-186 Compounds, New Inhibitors of Acyl-CoA: Cholesterol Acyltransferase from Penicillium asperosporum KY1635

Autor:	Yoshikazu Morishita, Katsuhiko Ando, Yuzuru Matsuda, Kazutoshi Kuroda, Yutaka Saito, Yoji Ikuina, Isao Kawamoto
Rok vydání:	2010
Předmět:	Biochemistry Chemistry Penicillium asperosporum Sterol O-acyltransferase Microsome Purpactin A Ic50 values ACAT activity General Medicine
Zdroj:	ChemInform. 25
ISSN:	0931-7597
DOI:	10.1002/chin.199431281
Popis:	AS-186a, b, c, d, and g were isolated from the cultured broth of Penicillium asperosporum KY1635 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). IC50 values for the effect of AS-186a, b, c, d, and g against ACAT activity of the microsomes from cholesterol-fed rabbit liver were calculated to be 22.9, 8.2, 11.5, 12.4, and 13.9 microM, respectively. Although AS-186a, and b were identical to penicillide and purpactin A, respectively, AS-186c, d, and g were found to be new compounds.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1f159d240524697a73679cc806c9fd94 https://doi.org/10.1002/chin.199431281 Zobrazit plný text záznamu Plný text