ChemInform Abstract: A Facile Synthesis of Benzo(b)thiophene Derivatives

Autor:	Kenji Kawanishi, Ryuji Akiyoshi, Mitsuaki Watanabe, Mutsuhiro Date, Sunao Furukawa
Rok vydání:	2010
Předmět:	chemistry.chemical_compound chemistry Formic acid Thiophene Organic chemistry General Medicine Thiophene derivatives
Zdroj:	ChemInform. 22
ISSN:	0931-7597
DOI:	10.1002/chin.199130163
Popis:	Lithiation of S-(2-methylphenyl) N, N, N', N'- tetramethylphosphorodiamidothioate with sec-BuLi at #75105° gave the corresponding benzylic anion which was acylated with various aromatic esters to give various deoxybenzoin derivatives in moderate to high yields. Acidic treatment of these products in refluxing formic acid gave 2-arylbenzo[b]thiophene derivatives. 2-Methylbenzo[b]thiophene and benzo[b]thiophen-2(3H)-one were also prepared using the similar procedure
Databáze:	OpenAIRE
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