Effect of Doxorubicin on Fibroblast Migration and Proliferation
| Autor: | L. Izaguirre, Francisco M. Honrubia, F. Gonzalvo, S. Perez, Isabel Pinilla |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
chemistry.chemical_classification
biology Cell growth business.industry Lysyl hydroxylase Molecular biology Fibroblast migration Ophthalmology medicine.anatomical_structure Enzyme chemistry Enzyme inhibitor Toxicity polycyclic compounds Cancer research biology.protein medicine Doxorubicin Fibroblast business medicine.drug |
| Zdroj: | Annals Of Ophthalmology. 35:48-52 |
| ISSN: | 1530-4086 |
| DOI: | 10.1385/ao:35:1:48 |
| Popis: | This study evaluated the effect of doxorubicin on fibroblast migration and proliferation. An artificial wound was made in a fibroblast monolayer, and doxorubicin was added. The cell-free area was monitored. Viability and proliferation were assessed by the cell proliferation reagent WST-1. Doxorubicin at 10−6M or greater inhibited migration. Proliferation was decreased with 2.5×10−5 or more of doxorubicin. Doses at 5×10−5M and at 10−4M showed cellular toxicity. Doxorubicin effectively inhibits wound repair. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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