Comparative In Vitro Study of Antiherpetic Activity of Echinochrome A and Product of Its Oxidation Dehydroechinochrome
| Autor: | Natalia V. Krylova, Natalia P. Mishchenko, Sergey A. Fedoreyev, Elena A. Vasileva, Olga V. Iunikhina, M. Yu Shchelkanov |
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| Rok vydání: | 2021 |
| Předmět: |
biology
Chemistry viruses General Medicine medicine.disease_cause General Biochemistry Genetics and Molecular Biology Virus Pigment Herpes simplex virus Biochemistry biology.animal visual_art medicine Vero cell visual_art.visual_art_medium In vitro study Scaphechinus mirabilis Echinochrome A Sea urchin |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 171:464-467 |
| ISSN: | 1573-8221 0007-4888 |
| Popis: | The quinoid pigment echinochrome A isolated from the sea urchin Scaphechinus mirabilis, the product of its oxidation dehydroechinochrome, and structurally similar antiviral agent oxolin were tested for their ability to inhibit plaque formation induced by herpes simplex virus type 1 (HSV-1) in Vero cells. The tested compounds showed significant anti-HSV-1 activity, mainly due to their direct effect on viral particles and on virus attachment to cells. The antiviral efficacy of the test compounds increased in the following order: oxolin→echinochrome A→dehydroechinochrome. |
| Databáze: | OpenAIRE |
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