Effects of the PCB 3,4,5,3′,4′,5′-hexachlorobiphenyl on the reproduction capacity of Wistar rats
| Autor: | A. E. Smits-van Prooije, J.H.C.M. Lammers, B.M. Kulig, D.H. Waalkens-Berendsen, N.J. Snoeij |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Food intake
medicine.medical_specialty Pregnancy Environmental Engineering Offspring Health Toxicology and Mutagenesis media_common.quotation_subject Public Health Environmental and Occupational Health General Medicine General Chemistry Biology medicine.disease Body weight Pollution Endocrinology Internal medicine Toxicity Dose group medicine Environmental Chemistry Gestation Reproduction media_common |
| Zdroj: | Chemosphere. 27:395-400 |
| ISSN: | 0045-6535 |
| DOI: | 10.1016/0045-6535(93)90318-y |
| Popis: | Groups of rats were administered different doses of the coplanar PCB 3,4,5,3′,4′,5′-hexachlorobiphenyl or vehicle on day 1 of gestation. Slight maternal toxicity was evidenced by temporarily reduced body weight and food intake of the highest dose groups. The effects observed on physical development of the offspring were minimal. In contrast, severe effects were observed on the reproduction capacity in the highest dose group in both males and females, either when male and female offspring was paired within the same dose group or when they were paired with untreated partners. In addition, indications of changes in sexual behaviour were observed, especially in males. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|