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Rats Wistar line were found to be a good laboratory model for the BLV infection pathogenesis studying. At the initial stage of infection, the rats’ first generation offspring were born healthy and colostral immunity protected them from infection for at least a month. Transplacental transmission of the virus to the rats’ second generation offspring was established in 30-33 % of experimental animals. The results of hematological studies have shown that in animals of experimental groups, thrombocytosis progressed over time and the average volume of platelets increased, which may be evidence of the megakaryocytic leukemia development. In some cases, there were signs of allergy, hemolytic anemia, lymphocytic leukemia. The most significant changes were found in the offspring of experimental rats. |
