1,2,3-Triazole-Containing 1,5,6,7-Tetrahydro-4H-indazol-4-ones and 6,7-Dihydrobenzo[d]isoxazol-4(5H)-ones: Synthesis and Biological Activity

Autor:	T. S. Khlebniсova, V. G. Zinovich, Yu. A. Piven, A. V. Baranovsky, F. A. Lakhvich, R. E. Trifonov, Yu. A. Golubeva, L. S. Klyushova, E. V. Lider
Rok vydání:	2023
Předmět:	General Chemistry
Zdroj:	Russian Journal of General Chemistry. 93:268-277
ISSN:	1608-3350 1070-3632
DOI:	10.1134/s1070363223020068
Popis:	Abstract Triazole-containing 1,5,6,7-tetrahydro-4H-indazol-4-ones and 6,7-dihydrobenzo[d]isoxazol-4(5H)-ones were synthesized by cyclocondensation of 2-[(1H-1,2,3-triazol-1-yl)acetyl]cyclohexane-1,3-diones with phenylhydrazine (4-fluorophenylhydrazine) or hydroxylamine, respectively. Structure and composition of the obtained compounds were confirmed by 1H, 13C, 19F NMR spectroscopy methods and by data of elemental analysis. Cytotoxic and cytostatic activities of the series of obtained compounds were investigated in vitro against human hepatocellular carcinoma cells HepG2, mammary adenocarcinoma cells MCF-7, and laryngeal cancer cells Hep2.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1eeb152055b5f40e3ef34adff96aba54 https://doi.org/10.1134/s1070363223020068 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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