Gradually increased stress levels in the days leading to an acute myocardial infarction, detected by a new biomarker-based approach

Autor: N Kosmas, D Zapantiotis, D Kitridis, E Kiouri, L S Rallidis
Rok vydání: 2022
Předmět:
Zdroj: European Heart Journal. 43
ISSN: 1522-9645
0195-668X
DOI: 10.1093/eurheartj/ehac544.1275
Popis: Background Stress has been recognized as a cardiovascular risk factor that aside from triggering acute coronary syndromes (acute stress), could also directly and indirectly mediate the pathophysiology of coronary artery disease (chronic stress). So far, there have been no quantitative indices available to study this relationship. Purpose We prospectively investigated stress levels for the days prior to the episode, on male patients with an acute myocardial infarction (AMI), by measuring the Hair Cortisol Concentration (HCC) which is indicative of cortisol blood levels. Methods A total of 95 consecutive male patients with AMI (ST-elevation MI and non-ST-elevation MI) wererecruited. Exclusion criteria were: age >80 years, presence of chronic inflammatory disease, endocrine/psychiatric disorder or malignancy. A small sample of hair was obtained from the patient's head and the hair segments were later analyzed for HCC, by an enzymatic analytical method that measures the amount of cumulative cortisol which was deposited from the bloodstream upon every piece, at the time when it was generated by the hair follicle. Results Results of mean HCC of patients, expressed as a percentage of the range detected were: 0 time: 75.41%, 15 days prior: 76.79%, 30 days prior: 72.88%, 45 days prior: 69.34%, 60 days prior: 69.43% and 75 days prior: 65.96%. Figure 1 shows HCC during 75 days prior to the day of AMI occurrence which is the day zero. The results are consistent with a gradual increase in HCC, which reflects stress levels, in the days before the AMI, which peaked 15 days before the episode. Conclusions Stress levels, as quantified by a new biomarker-based approach, are gradually increased in the days preceding an AMI, peaking at 15 days before the episode. Funding Acknowledgement Type of funding sources: None.
Databáze: OpenAIRE
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