Prolonged unconjugated hyperbilirubinaemia associated with the haem oxygenase-1 gene promoter polymorphism
| Autor: | Ayfer Ülgenalp, Didem Cemile Yesilirmak, Derya Erçal, Hasan Ozkan, Abdullah Kumral, Özlem Giray Bozkaya, Nuray Duman |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry Bilirubin Single-nucleotide polymorphism General Medicine Breast milk Jaundice chemistry.chemical_compound Endocrinology chemistry Polymorphism (computer science) Internal medicine Pediatrics Perinatology and Child Health Immunology Genotype Medicine Allele medicine.symptom business Allele frequency |
| Zdroj: | Acta Paediatrica. 99:679-683 |
| ISSN: | 0803-5253 |
| Popis: | Aim: To elucidate the genetic factors causing hyperbilirubinaemia in prolonged jaundice of the newborns, we investigated whether the HO-1 gene promoter polymorphism is a cause in unexplained pathological or prolonged jaundice. Methods: Three groups were defined: healthy newborns with no clinical jaundice, newborns hospitalized for jaundice without any identifiable pathological cause and newborns with prolonged jaundice associated with breast milk. Genomic DNA was extracted from the white blood cells and the promoter region of the HO-1 gene was amplified using PCR and their allelic repeats were determined. Results: We did not detect any significant difference in the allele frequencies between the healthy newborns and the newborns whose serum total bilirubin levels were >12.9 mg/dL. However, the patients with short ( |
| Databáze: | OpenAIRE |
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