| Autor: |
Wenliang Ji, Xiangjiang Rong, Yongzhao Fan, Yuhan Wang, Kun Liu |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
DEStech Transactions on Computer Science and Engineering. |
| ISSN: |
2475-8841 |
| DOI: |
10.12783/dtcse/cib2015/16163 |
| Popis: |
Physical exercise has been demonstrated to be neuroprotective in ischemia models. However, the exact neuroprotective mechanism needs to be further studied. The purpose of this research is to discuss the effect of pre-ischemic voluntary wheel running on levels of dopamine in the striatum and cognition in ischemia rats. 12 Sprague-Dawley rats were divided randomly in following two groups: 0 week pre-ischemia wheel running （0-WR ）group and 4 weeks pre-ischemia wheel running （4-WR ）group. After training, global cerebral ischemia was induced by two-vessel occlusion (2-VO). Microdialysis and high performance liquid chromatography system (HPLC) were used to collect and determine dopamine in the dialysates of striatum. Passive avoidance was used to test cognitive function 24 h after ischemia. The results showed that striatal dopamine of 0-WR group was rapid increasing after ischemia, but the increase of striatal dopamine level was attenuated in 4 weeks group. Behavioral data indicated that voluntary wheel running promoted cognition recovery after ischemia. Thus, pre-ischemia voluntary wheel running attenuates the increase of dopamine of striatum induced by cerebral ischemia and improves cognitive function in ischemia rats. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
