Abstract TP166: Association Of Hemoglobin Trend And Outcome In Aneurysmal Subarachnoid Hemorrhage
| Autor: | Asghar Shah, Ryan Snow, Christoph Stretz, Nicholas S Potter, Linda C Wendell, Bradford B Thompson, Michael Reznik, Karen L Furie, Ali Mahta |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Stroke. 53 |
| ISSN: | 1524-4628 0039-2499 |
| Popis: | Introduction: Anemia has been linked to delayed cerebral ischemia and worse outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). However, the association of hemoglobin (Hb) trend on outcomes has not been well studied. We sought to determine predictors of Hb trend and its association with outcomes in aSAH. Methods: We conducted a retrospective cohort study of consecutive patients with aSAH who were admitted to an academic center from 2016 through 2021. Multiple linear regression analysis was used to identify factors associated with Hb difference from admission to discharge (continuous variable). Binary logistic regression analysis was used to test the association of Hb values (on admission, discharge, trend and difference from admission to discharge) with outcome measures including vasospasm (based on transcranial Doppler criteria) and worse functional outcome defined as modified Rankin scale (mRS) 4-6 at 3 months after discharge. Results: We included 312 patients with confirmed aneurysmal etiology (mean age 57 years, SD13.6; 62% female; 70% white). Mean Hb on admission was 13.5 g/dl (SD 1.7) and on discharge was 11.1 g/dl (SD 2). Forty-three patients (14%) required blood transfusions. Greater Hb drop from admission to discharge was independently associated with higher risk of vasospasm (OR 1.16, 95% CI 1.02-1.30; p=0.018) but not worse outcome after adjustment for age, sex, Hb on admission, Hunt and Hess grades, modified Fisher scales. Predictors of Hb drop on multiple linear regression analysis were lower Hb on admission (beta=0.61, p Conclusions: Greater hemoglobin drop was associated with higher risk of vasospasm but unlike lower Hb at discharge, it was not associated with worse outcome. Further studies are needed to use Hb trend to guide transfusion threshold in these patients. |
| Databáze: | OpenAIRE |
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