A Novel Adsorbent for Hydrophilic Chromatography Based on Silica Modified by the Ugi Reaction

Autor:	D. E. Bryskina, A. A. Komarov, Andrey Stavrianidi, A. O. Shemyakina, A. V. Chernobrovkina, M. A. Statkus, N. Yu. Chikurova, V. N. Nuriev
Rok vydání:	2021
Předmět:	Solvent chemistry.chemical_compound Adsorption Chromatography Ethanol chemistry Hydrophilic interaction chromatography Acetone Ugi reaction Selectivity Glycolic acid Analytical Chemistry
Zdroj:	Journal of Analytical Chemistry. 76:1083-1092
ISSN:	1608-3199 1061-9348
Popis:	New stationary phases for hydrophilic chromatography (HILIC) with functional layers formed by the multicomponent Ugi reaction have been obtained. Acetone, glycolic acid, ethyl isocyanacetate, and 3‑aminopropyl silica, which also act as adsorbent matrices, were used as reaction components. The study of the effect of solvent on the reaction yield showed that a high degree of coverage of the matrix was achieved when the reaction was carried out in ethanol. The new adsorbents’ chromatographic properties compared with the initial matrix were assessed using the Tanaka tests for hydrophilic phases and by studying the retention of polar analytes from various classes. The synthesized adsorbents have demonstrated high efficiency and selectivity in separating model mixtures of sugars, amino acids, and water-soluble vitamins in the HILIC mode.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1ed004f8b11214d737dc0d3f15a1b531 https://doi.org/10.1134/s1061934821090033 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.