COPD and OSA: Can the overlap syndrome be suspected by clinical symptoms
| Autor: | Francis Lopes Pacagnelli, Maiara Almeida Aldá, Flávio Danilo Mungo Pissulin, Jefferson Luis de Barros, Ricardo Beneti, Silke Anna Theresa Weber |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
education.field_of_study COPD Adiponectin medicine.diagnostic_test business.industry Epworth Sleepiness Scale Population Group ii Excessive daytime sleepiness Overlap syndrome Polysomnography medicine.disease nervous system diseases respiratory tract diseases Internal medicine medicine Physical therapy medicine.symptom business education |
| Zdroj: | 4.2 Sleep and Control of Breathing. |
| DOI: | 10.1183/13993003.congress-2016.pa2355 |
| Popis: | Introduction: Overlap of COPD and OSA seems to be frequent, whereas prevalence, identification by screening methods still require investigation. Objectives: To determine the frequency of OSA symptoms and diagnosis of OSA in COPD patients. Methods: This cross-sectional study invited COPD patients, ranked by GOLD. All realized polysomnography, Epworth Sleepiness Scale (ESS), Berlin Questionnaire (BQ), SGRQ, BDI, MMRC, beside biochemical exams as total cholesterol and fractions, interleukin 6 (IL-6), leptin and adiponectin. Patients were divided in 2 groups by OSA diagnosis (Group I COPD+OSA, Group II COPD-OSA) and demographic data, clinical symptoms and biochemical exams were compared Results: 86 COPD patients, 38 men, mean age 61.2 years, were included. OSA was diagnosed in 61 (67.4%) patients, 31 men, 15 with severe OSA. Both groups showed no difference for age, BMI, metabolic markers. OSA screening (BQ) was highly positive in both groups (p>0.05), excessive daytime sleepiness(ESS) was poorly related in both groups (p>0.05). Beside severe and very severe COPD being more frequent in Group II, minimum oxygen saturation was significantly lower in OSA patients (GI-75.9+-9.7 vs GII 84.2+-9.8,p=0.0004). Conclusion: COPD patients seem to be at higher risk for OSA compared to the general population. Excessive daytime sleepiness was not frequently related, screening questionnaires as Berlin showed poor correlation to the PSG diagnosis of OSA, thus, polysomnography should be considered for the diagnostic tool. The presence of OSA did not influence the patient´s perception of health impairment or of dyspnea. Metabolic status was not worsened in OSA patients. |
| Databáze: | OpenAIRE |
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