Guidelines for genomic array analysis in acquired haematological neoplastic disorders
| Autor: | Marian Stevens-Kroef, Javier Suela, H. Berna Beverloo, Katrina Rack, Dominique Muehlematter, Eva van den Berg, Ros Hastings, Jacqueline Schoumans |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Cancer Research Microarray Microarray analysis techniques Hematologic Neoplasms Disease Computational biology Biology medicine.disease 03 medical and health sciences 030104 developmental biology 0302 clinical medicine 030220 oncology & carcinogenesis Immunology Genetics medicine Multiple myeloma Virtual karyotype Comparative genomic hybridization |
| Zdroj: | Genes, Chromosomes and Cancer. 55:480-491 |
| ISSN: | 1045-2257 |
| DOI: | 10.1002/gcc.22350 |
| Popis: | Genetic profiling is important for disease evaluation and prediction of prognosis or responsiveness to therapy in neoplasia. Microarray technologies, including array comparative genomic hybridization and single-nucleotide polymorphism-detecting arrays, have in recent years been introduced into the diagnostic setting for specific types of haematological malignancies and solid tumours. It can be used as a complementary test or depending on the neoplasia investigated, also as a standalone test. However, comprehensive and readable presentation of frequently identified complex genomic profiles remains challenging. To assist diagnostic laboratories, standardization and minimum criteria for clinical interpretation and reporting of acquired genomic abnormalities detected through arrays in neoplastic disorders are presented. |
| Databáze: | OpenAIRE |
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