| Autor: |
Qijun Zhang, Kazuyuki Kasahara, Julia H. Kemis, Helen E. Blackwell, Kathryn L. Schueler, Marcus M. Seldin, Gregory R. Keele, Joshua J. Coon, Gary A. Churchill, Thiru R. Reddy, Jason D. Russell, Thomas J Polaske, Donald S. Stapleton, Vanessa Linke, Mary E. Rabaglia, Alan D. Attie, Mark P. Keller, Daniel E Manson, Ian J. Miller, Edna A. Trujillo, Katherine A. Overmyer, Daniel M. Gatti, Robert L. Kerby, Lindsay L. Traeger, Aldons J. Lusis, Duy Pham, Federico E. Rey, Karl W. Broman, Eugenio I. Vivas, Joseph P. Gerdt |
| Rok vydání: |
2021 |
| Předmět: |
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| Popis: |
The molecular bases of how host genetic variation impact gut microbiome remain largely unknown. Here, we used a genetically diverse mouse population and systems genetics strategies to identify interactions between molecular phenotypes, including microbial functions, intestinal transcripts and cecal lipids that influence microbe-host dynamics. Quantitative trait loci (QTL) analysis identified genomic regions associated with variations in bacterial taxa, bacterial functions, including motility, sporulation and lipopolysaccharide production, and levels of bacterial- and host-derived lipids. We found overlapping QTL for the abundance of Akkermansia muciniphila and cecal levels of ornithine lipids (OL). Follow-up studies revealed that A. muciniphila is a major source of these lipids in the gut, provided evidence that OL have immunomodulatory effects and identified intestinal transcripts co-regulated with these traits. Collectively, these results suggest that OL are key players in A. muciniphila-host interactions and support the role of host genetics as a determinant of responses to gut microbes. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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