Analytical Procedure for the Quantification of in vitro Induced Pt- and Pd-DNA Adducts in Human Lung Cells

Autor:	Doris Stüben, Jörg-Detlef Eckhardt, Christoph M. Menzel, Andrea Hartwig, Andreas Zeller, Zsolt Berner
Rok vydání:	2006
Předmět:	Reproducibility chemistry.chemical_compound Chromatography medicine.anatomical_structure Chemistry medicine A-DNA Repeatability DNA extraction DNA In vitro Adduct Human lung
Zdroj:	Palladium Emissions in the Environment ISBN: 3540292195
DOI:	10.1007/3-540-29220-9_16
Popis:	A combined analytical procedure is presented for the quantification of experimentally induced Pt and Pd DNA adducts in living cells by combining a DNA extraction technique with double focusing magnet sector field ICP-MS instrumentation. The proposed method is discussed in terms of possible spectral interferences, instrumental repeatability and experimental reproducibility. The statistical evaluation of a large dataset indicates that the method can be successfully used in experimental studies for the quantification of Pt and Pd DNA adducts.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1eb4f5db10f672e91729202ce94f37b5 https://doi.org/10.1007/3-540-29220-9_16 Zobrazit plný text záznamu