First Report on HHV-6 Infection Among HIV-Infected Individuals Residing in Surabaya, Indonesia
| Autor: | Ni Luh Ayu Megasari, Soetjipto, Maria Inge Lusida, Elsa Fitri Ana, Nasronudin, Devi Oktafiani |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Epidemiology
HHV-6 Infection viruses medicine.medical_treatment Human immunodeficiency virus (HIV) Dermatology Disease 030312 virology medicine.disease_cause Peripheral blood mononuclear cell 03 medical and health sciences 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) Virology Hiv infected medicine 030212 general & internal medicine 0303 health sciences business.industry Health Policy virus diseases Immunosuppression Odds ratio medicine.disease Infectious Diseases Immunology business |
| Zdroj: | HIV/AIDS - Research and Palliative Care. 12:107-112 |
| ISSN: | 1179-1373 |
| DOI: | 10.2147/hiv.s232146 |
| Popis: | Background Morbidity and mortality from acquired immunodeficiency syndrome (AIDS) are often associated with the reactivation of a herpes virus infection. Human herpesvirus-6 (HHV-6) is usually common in childhood infections that remain latent and can act as opportunists during immunosuppression to reactivate and cause disease. In human immunodeficiency virus (HIV)-infected patients, the impact of HHV-6 infection can be an up-regulator of HIV replication and accelerate progress towards AIDS. However, studies on HHV-6 infection have never been done in Surabaya, Indonesia. Purpose To determine the presence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia. Patients and methods Plasma and peripheral blood mononuclear cells (PBMCs) were collected from 85 HIV-infected individuals in Universitas Airlangga Hospital, Surabaya, as well as 85 healthy controls. DNA extracted from PBMCs was subjected to PCR to determine HHV-6 infection, while plasma of HIV-infected individuals was used for viral RNA quantification using real-time PCR. Results HHV-6 infection was detected in 17.6% (15/85) of HIV-infected individuals, and in 3.53% (3/85) of healthy controls. Thus, HHV-6 infection was more likely to be found in HIV-infected individuals than in healthy controls (odds ratio 5.85; 95% confidence interval, 1.6-21). The HHV-6B was the most common subtype identified in both HIV-infected individuals (12/15) and healthy controls (3/3). The HHV-6A and co-infection between HHV-6A and HHV-6B were only found in HIV-infected individuals (2/15 and 1/15, respectively). Viral RNA load of HIV-infected individuals was not correlated to HHV-6 infection. Conclusion Our results indicate the emergence of HHV-6 infection among HIV-infected individuals residing in Surabaya, Indonesia, and the risk of HHV-6 infection was higher in HIV-infected individuals than in healthy controls. |
| Databáze: | OpenAIRE |
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