A facile synthesis of tetracyclic benzo-pyridonaphthyridines by domino reaction

Autor:	Subramanya Hosahalli, Rangarao Pallepati, Vishnu Basetti, Vijay Potluri
Rok vydání:	2013
Předmět:	chemistry.chemical_compound Cascade reaction Chemistry Organic Chemistry Drug Discovery Sulfuric acid Protonation Dimethylformamide-dimethylacetal Biochemistry Medicinal chemistry Dimethylamine Enamine
Zdroj:	Tetrahedron Letters. 54:2014-2017
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.02.016
Popis:	A novel methodology for the synthesis of tetracyclic benzo-pyridonaphthyridines, forming a C–C and a C–N bond in concentrated sulfuric acid at 70 °C in a one-pot is reported. The key substrates (9a–m) are prepared by reacting 2-chloro-6-(4-fluorophenyl)-4-methylnicotinenitrile (7) with various anilines followed by dimethylformamide dimethylacetal. The domino reaction is initiated by the protonation of the β-carbon of the enamine group in 9a–m and terminated by the elimination of dimethylamine.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::1eb07db8325bee7b53427b2f4dae57cc https://doi.org/10.1016/j.tetlet.2013.02.016 Zobrazit plný text záznamu Full Text from ScienceDirect